Questions/Réponses

 

Neurovascular determinants of cognitive impairment: emerging role of cerebral endothelial cells

Costantino Iadecola

 

QUESTION : Thanks for a brillant talk! is there in your opinion specific behavioral test that would be more relevant or more implying a vascular component of the cognitive decline?

ANSWER : Thank you for the kind words and your question. In humans, vascular cognitive impairment is associated mainly with executive dysfunction and psychomotor slowing, memory can be affected but tends to be later. In rodents, there is no specific test, but the nesting test is considered a test of executive function

 

QUESTION : : What about cholesterol accumulation in the vascular wall

ANSWER : Thank you for your question, cerebrovascular atherosclerosis is a major pathogenic factor in cognitive impairment. Recent data indicate that is involved not only in vascular cognitive impairment but also in Alzheimer’s disease (AD). Patients with AD have more intracranial athero, and a recent study (Wingo et al Nat Neurosci, 2020) suggests that the effect of atherosclerosis is a pathogenic factor independent of amyloid and tau.

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